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Patients who lose 5–10% of body weight typically see additional cholesterol improvements beyond the direct GLP-1 effects, creating a synergistic benefit
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A meta-analysis of 12 randomized controlled trials (n = 17,996) further confirmed these renoprotective effects, with agents structurally closer to endogenous human GLP-1, such as semaglutide, showing the strongest benefit (RR = 0.78, 95% CI: 0.71–0.85) ( 3.4 Hepatic protection In clinical practice, semaglutide has demonstrated notable efficacy in resolving NASH without aggravating hepatic fibrosis
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